Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression
نویسندگان
چکیده
منابع مشابه
Gene Expression of CD226 and Its Serum Levels in Patients With Multiple Sclerosis
Background: Recent studies have found some genetic variants as a risk factor for autoimmune diseases such as Multiple Sclerosis (MS). Cluster of Differentiation 226 (CD226) is one of the risk factors for MS. Objectives: The present study aimed to evaluate the gene expression of CD226, and its protein serum level in peripheral blood samples of MS patients and healthy individuals. Materials & ...
متن کاملNon-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases.
OBJECTIVES Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in n...
متن کاملMining Gene Expression Data of Multiple Sclerosis
OBJECTIVES Microarray produces a large amount of gene expression data, containing various biological implications. The challenge is to detect a panel of discriminative genes associated with disease. This study proposed a robust classification model for gene selection using gene expression data, and performed an analysis to identify disease-related genes using multiple sclerosis as an example. ...
متن کاملCD226 rs763361 Is Associated with the Susceptibility to Type 1 Diabetes and Greater Frequency of GAD65 Autoantibody in a Brazilian Cohort
CD226 rs763361 variant increases susceptibility to type 1 diabetes (T1D) in Caucasians. There is no data about CD226 variants in the very heterogeneous Brazilian population bearing a wide degree of admixture. We investigated its association with T1D susceptibility, clinical phenotypes, and autoimmune manifestations (islet and extrapancreatic autoantibodies). Casuistry. 532 T1D patients and 594 ...
متن کاملMarburg's variant of multiple sclerosis.
A 32 years female presented with sequential weakness of left half, followed by right half of body during last two and half months without any remission. she had muscle spasms, urinary retention and constipation for same duration. she had periorbital pain but no visual or hearing problem. she had no preceeding respiratory infection or vaccination. she had two abortions. she could not talk proper...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1618520114